Description

Elenbecestat (E2609) is a potent and selective small molecule inhibitor of the β-site amyloid precursor protein cleaving enzyme 1 (BACE1), a key target in Alzheimer's disease research. This high-purity compound is essential for advancing pre-clinical and clinical studies aimed at modulating amyloid-beta peptide production. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and CROs focused on neurodegenerative disease therapeutics and central nervous system drug discovery.

Application

• Alzheimer's Disease Research: Critical for in vitro and in vivo studies investigating BACE1 inhibition and amyloid-beta pathology.
• Pharmacological Profiling: Used in enzyme activity assays, cellular models, and animal studies to determine efficacy and mechanism of action.
• Drug Discovery & Development: Serves as a reference standard and active pharmaceutical ingredient (API) in the development of novel therapeutic candidates.
• Biochemical Research: Employed in structural biology and molecular modeling to study enzyme-inhibitor interactions.
• Clinical Trial Materials: Supplied as a high-grade compound for formulation studies and the manufacture of clinical trial supplies under GMP guidelines where applicable.

Basic Information

Product Name	Elenbecestat (E2609)
CAS No.	1388651-30-6
Molecular Formula	C24H21F2N3O5
Molecular Weight	469.44 g/mol
Synonyms	E2609; BAN2401 (Note: BAN2401 is often associated with a related antibody; verify context); (1R,2S)-2-(2-Fluoro-6-((S)-3-methylmorpholino)pyridin-3-yl)-6-(3-methyl-1H-pyrazol-1-yl)-3,4-dihydro-2H-chromen-3-amine; β-Secretase Inhibitor E2609; BACE1 Inhibitor E2609; Elenbecestat free base
EINECS	Contact for details

Quality Control

Our Elenbecestat (E2609) is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant ICH guidelines for stability and impurity characterization, and can supply material suitable for pre-clinical development under controlled conditions.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the certificate of analysis. For long-term storage, consider storing desiccated at -20°C. Handle and store in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.