Description

Elenbecestat CAS NO 1388149-30-1 is a potent and selective small-molecule inhibitor of the β-site amyloid precursor protein cleaving enzyme 1 (BACE1). This compound matters as a key research tool and pharmaceutical intermediate in the development of novel therapeutics targeting Alzheimer's disease pathology. It is primarily needed by pharmaceutical R&D laboratories, biotechnology companies, and academic research institutions focused on neurodegenerative disease mechanisms and drug discovery.

Application

• Pharmaceutical Research & Development: As a critical reference standard and active pharmaceutical ingredient (API) intermediate in the development of BACE1 inhibitor therapies for Alzheimer's disease.
• Biochemical Assay Development: For use in high-throughput screening (HTS) campaigns and enzymatic assays to study BACE1 inhibition kinetics and potency.
• Mechanistic Studies: Employed in preclinical research to investigate the role of β-amyloid (Aβ) production and its modulation in cellular and animal models of neurodegeneration.
• Drug Discovery Pipeline: Serves as a lead compound or a structural template for the design and synthesis of next-generation BACE1 inhibitors with improved pharmacokinetic profiles.
• Quality Control & Analytical Testing: Used as a certified reference material (CRM) for the identification and quantification of elenbecestat in drug substances and finished dosage forms via HPLC, LC-MS, or NMR.
• Academic Research: A vital tool for universities and research institutes studying amyloid precursor protein (APP) processing and the pathophysiology of Alzheimer's disease.

Basic Information

Product Name	Elenbecestat
CAS No.	1388149-30-1
Molecular Formula	C24H22F2N4O5
Molecular Weight	484.45 g/mol
Synonyms	Elenbecestat; BAN2401; E2609; (1R,2S)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-6-[(3S)-3-(methylsulfonyl)pyrrolidin-1-yl]hexan-1-ol; 6-[(3S)-3-(Methylsulfonyl)pyrrolidin-1-yl]-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)hexan-1-ol; (1R,2S)-6-[(3S)-3-(Methylsulfonyl)-1-pyrrolidinyl]-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-1-hexanol; Eisai E2609; BACE1 Inhibitor E2609.
EINECS	Contact for details

Quality Control

Our Elenbecestat is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting high standards for pharmaceutical research. Certificates of Analysis (COA) detailing specifications such as HPLC purity, chiral purity, residual solvents, and heavy metals are available upon request. We support compliance with relevant guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.