Description

8-Fluoro-5-Methoxy-1,2,3,4-Tetrahydroquinoline is a high-purity fluorinated tetrahydroquinoline derivative, a privileged scaffold in modern medicinal chemistry. Its core value lies in its role as a versatile and critical building block for the synthesis of novel pharmaceutical compounds, particularly in central nervous system (CNS) and oncology research. This intermediate is essential for research and development chemists, process chemists, and manufacturers in the pharmaceutical, agrochemical, and advanced material sectors seeking to introduce specific fluorine and methoxy substitutions into complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, especially in CNS-targeted therapies and oncology.
• Agrochemical Research: Used in the synthesis of advanced active ingredients for crop protection products.
• Material Science: Serves as a precursor for functionalized organic molecules used in electronic materials or liquid crystals.
• Chemical Biology: Employed as a probe or labeling agent in biochemical research due to its fluorinated structure.
• Academic & Industrial R&D: Fundamental building block for method development and exploring new chemical spaces in heterocyclic chemistry.
• Process Chemistry: Scalable intermediate for optimizing synthetic routes toward target molecules in kilo-lab and pilot plant settings.

Basic Information

Product Name	8-Fluoro-5-Methoxy-1,2,3,4-Tetrahydroquinoline
CAS No.	1388051-58-8
Molecular Formula	C10H12FNO
Molecular Weight	181.21 g/mol
Synonyms	5-Methoxy-8-fluoro-1,2,3,4-tetrahydroquinoline; 8-Fluoro-5-methoxy-1,2,3,4-tetrahydroquinoline; 1,2,3,4-Tetrahydro-8-fluoro-5-methoxyquinoline; 8-Fluoro-5-methoxy-THQ; FMO-THQ; Fluoromethoxy tetrahydroquinoline
EINECS	Contact for details

Quality Control

Our 8-Fluoro-5-Methoxy-1,2,3,4-Tetrahydroquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider inert atmosphere conditions to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.