Description

Dbco-(Ch2)3-Nh2.Tfa is a functionalized DBCO (dibenzocyclooctyne) derivative, a key reagent in bioorthogonal click chemistry. Its primary value lies in its ability to undergo rapid, catalyst-free strain-promoted azide-alkyne cycloaddition (SPAAC) reactions with azide-functionalized molecules. This compound is essential for researchers and manufacturers in bioconjugation, pharmaceutical development, and advanced materials science, enabling the precise labeling and crosslinking of biomolecules, polymers, and surfaces under mild, physiological conditions.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Development: Site-specific labeling of proteins, antibodies, and peptides for therapeutic and diagnostic applications.
• Probe and Sensor Synthesis: Construction of fluorescent, biotin, or other reporter-tagged molecules for imaging and detection assays.
• Polymer and Biomaterial Functionalization: Modification of hydrogels, nanoparticles, and surfaces with bioactive ligands for tissue engineering and drug delivery systems.
• Chemical Biology and Proteomics: Labeling of cellular components and activity-based protein profiling (ABPP) to study biological processes.
• Diagnostic Kit Manufacturing: Immobilization of capture molecules on lateral flow assay strips or microarray chips.
• Nucleic Acid Labeling: Conjugation of oligonucleotides for FISH probes, sequencing, or therapeutic oligonucleotide constructs.

Basic Information

Product Name	Dbco-(Ch2)3-Nh2.Tfa
CAS No.	1386999-75-2
Molecular Formula	C₂₀H₁₇F₃N₂O₃
Molecular Weight	390.36 g/mol
Synonyms	DBCO-Amine TFA Salt; DBCO-C3-Amine TFA; 3-((1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethylamino)-N-(3-aminopropyl)propanamide Trifluoroacetate; Dibenzocyclooctyl-PEG3-Amine TFA; DBCO-PEG3-Amine TFA; Amine-PEG3-DBCO TFA Salt; (1R,8S,9s)-N-(3-Aminopropyl)-3-(bicyclo[6.1.0]non-4-yn-9-ylmethylamino)propanamide 2,2,2-trifluoroacetate
EINECS	Contact for details

Quality Control

Our Dbco-(Ch2)3-Nh2.Tfa is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting applications in GMP-compatible and research-grade workflows.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.