Description

2-Chloro-5-(Trifluoromethyl)Cinnamic Acid is a high-value fluorinated cinnamic acid derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its molecular structure, featuring both chloro and trifluoromethyl substituents, provides unique electronic and steric properties essential for constructing complex molecules. This compound is primarily sought after by research institutions and pharmaceutical developers for applications in medicinal chemistry and agrochemical synthesis.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of anti-inflammatory and anticancer agents.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Research: Serves as a monomer or precursor for developing specialty polymers and liquid crystals with tailored optical and electronic properties.
• Organic Synthesis: A versatile reagent for constructing complex organic frameworks via reactions such as Heck coupling, cycloadditions, and as a precursor for other fluorinated compounds.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and protein-ligand interactions.

Basic Information

Product Name	2-Chloro-5-(Trifluoromethyl)Cinnamic Acid
CAS No.	1386504-00-2
Molecular Formula	C10H6ClF3O2
Molecular Weight	250.60 g/mol
Synonyms	(2E)-3-[2-Chloro-5-(trifluoromethyl)phenyl]prop-2-enoic acid; (E)-2-Chloro-α,β-difluoro-β-(trifluoromethyl)cinnamic Acid; 2-Chloro-α,β,β-trifluorocinnamic Acid; 3-(2-Chloro-5-(trifluoromethyl)phenyl)acrylic acid; (E)-3-(2-Chloro-5-(trifluoromethyl)phenyl)acrylic Acid; 2-Chloro-5-(trifluoromethyl)trans-cinnamic Acid
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-(Trifluoromethyl)Cinnamic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.