Description

4-[(2-Fluorophenyl)Methyl]Oxan-4-Ylmethanamine Hydrochloride is a high-purity, fluorinated organic building block with a hydrochloride salt form, offering enhanced stability and handling properties. This compound is a critical intermediate in modern pharmaceutical research and development, particularly valued for its unique structural motif that combines a fluorinated aromatic ring with a tetrahydropyranyl amine. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to introduce specific fluorine-containing pharmacophores into novel active molecules.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel drug candidates, especially in central nervous system (CNS) and oncology research pipelines.
• Medicinal Chemistry Research: Used for structure-activity relationship (SAR) studies and lead optimization due to the fluorine atom's ability to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Acts as a precursor in the development of new-generation pesticides and herbicides, where the fluorine moiety enhances biological activity.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and protein-ligand interactions.
• Process Chemistry Development: Used in scaling up synthetic routes for active pharmaceutical ingredients (APIs) under Good Manufacturing Practice (GMP) conditions.
• Custom Synthesis & Contract Manufacturing: A starting material for custom synthesis projects requiring specific fluorinated chiral amine derivatives.

Basic Information

Item	Details
Product Name	4-[(2-Fluorophenyl)Methyl]Oxan-4-Ylmethanamine Hydrochloride
CAS No.	1385696-57-0
Molecular Formula	C13H19ClFNO
Molecular Weight	259.75 g/mol
Synonyms	4-[(2-Fluorobenzyl)oxy]tetrahydro-2H-pyran-4-methanamine hydrochloride; 4-(Aminomethyl)-4-[(2-fluorophenyl)methyl]tetrahydro-2H-pyran hydrochloride; 4-[(2-Fluorobenzyl)oxy]tetrahydropyran-4-methanamine HCl; 2-Fluoro-α-((4-(aminomethyl)tetrahydro-2H-pyran-4-yl)methyl)benzenemethanol hydrochloride; (4-((2-Fluorobenzyl)oxy)tetrahydro-2H-pyran-4-yl)methanamine hydrochloride
EINECS	Contact for details

Quality Control

Our 4-[(2-Fluorophenyl)Methyl]Oxan-4-Ylmethanamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure compliance with stringent industry standards. Certificates of Analysis (COA) detailing all specifications are available upon request, supporting your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.