Description

5,8-Difluoro-1,2,3,4-Tetrahydroquinoline Hydrochloride is a high-purity, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters because its unique scaffold, featuring a tetrahydroquinoline core with strategic fluorine substitutions, is crucial for modulating the physicochemical and biological properties of target molecules. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients, particularly where enhanced metabolic stability, lipophilicity, or receptor binding affinity is desired.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, especially in central nervous system (CNS) and oncology therapeutic areas.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, where the fluorine atoms can improve bioactivity and environmental stability.
• Chemical Biology Probe Development: Serves as a versatile scaffold for creating molecular probes to study enzyme function and biological pathways.
• Material Science Precursor: Potential use in the synthesis of advanced organic materials, such as ligands for catalysts or components for organic electronics.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and production under cGMP conditions for clinical trial materials.

Basic Information

Product Name	5,8-Difluoro-1,2,3,4-Tetrahydroquinoline Hydrochloride
CAS No.	1384677-35-3
Molecular Formula	C9H8F2N•HCl
Molecular Weight	203.62 g/mol (Free base: 167.16 g/mol)
Synonyms	5,8-Difluoro-1,2,3,4-tetrahydroquinoline HCl; 5,8-Difluoro-1,2,3,4-tetrahydroquinoline hydrochloride; 1,2,3,4-Tetrahydro-5,8-difluoroquinoline hydrochloride; 5,8-Difluoro-3,4-dihydro-2H-quinoline hydrochloride; 1384677-35-3
EINECS	Contact for details

Quality Control

Our 5,8-Difluoro-1,2,3,4-Tetrahydroquinoline Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and KF titration for moisture content, to ensure it meets the stringent requirements for research and development. Certificates of Analysis (COA) with complete batch data are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.