Description

4-(2,2,2-Trifluoroethyl)Piperidine Hydrochloride is a high-purity, advanced pharmaceutical intermediate and building block of significant interest in modern synthetic chemistry. Its core value lies in the strategic incorporation of a trifluoroethyl group onto the piperidine scaffold, a modification known to dramatically influence the metabolic stability, lipophilicity, and binding affinity of target molecules. This compound is essential for research and development teams in the pharmaceutical and agrochemical sectors who are engaged in the discovery of new bioactive compounds, particularly for central nervous system (CNS) targets and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel Active Pharmaceutical Ingredients (APIs), especially for neurological and psychiatric disorders.
• Agrochemical Research: Used in the development of new generation pesticides and herbicides, where the trifluoroethyl group can enhance biological activity and environmental persistence.
• Medicinal Chemistry: Serves as a key scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Ligand & Catalyst Development: Employed in the creation of specialized ligands and organocatalysts for asymmetric synthesis.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A starting material for custom synthesis projects requiring fluorinated piperidine derivatives.

Basic Information

Product Name	4-(2,2,2-Trifluoroethyl)Piperidine Hydrochloride
CAS No.	1384428-45-8
Molecular Formula	C7H12ClF3N
Molecular Weight	202.62 g/mol
Synonyms	4-(2,2,2-Trifluoroethyl)piperidine HCl; 1-(2,2,2-Trifluoroethyl)piperidin-4-amine hydrochloride; 4-(Trifluoroethyl)piperidine hydrochloride; Piperidine, 4-(2,2,2-trifluoroethyl)-, hydrochloride; 1384428-45-8
EINECS	Contact for details

Quality Control

Our 4-(2,2,2-Trifluoroethyl)Piperidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity (typically >97% by HPLC), residual solvents, and other critical parameters is provided with every shipment to guarantee reliable and reproducible performance in your synthetic workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.