Description

1,1-Difluoropropan-2-Amine Hydrochloride CAS NO 1384427-90-0 is a high-purity, organofluorine building block essential for advanced chemical synthesis. This compound is valued for its role in introducing the difluoromethylamine moiety, a key structural feature that can modulate the physicochemical and metabolic properties of target molecules. It is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, metabolic diseases, and oncology.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, where the difluoroamine group can enhance bioavailability and biological activity.
• Fluorine Chemistry & SAR Studies: Enables structure-activity relationship (SAR) studies by serving as a versatile precursor for introducing fluorinated groups to optimize potency, selectivity, and metabolic stability.
• Peptidomimetics & Bioisosteres: Functions as a bioisostere for amides or other functional groups in the design of peptide mimics and other biologically active compounds.
• Material Science Precursor: Potential use as a monomer or specialty additive in the synthesis of advanced polymers and materials with unique surface properties.

Basic Information

Product Name	1,1-Difluoropropan-2-Amine Hydrochloride
CAS No.	1384427-90-0
Molecular Formula	C3H8ClF2N
Molecular Weight	131.55 g/mol
Synonyms	2-Amino-1,1-difluoropropane Hydrochloride; 1,1-Difluoro-2-aminopropane Hydrochloride; 1,1-Difluoropropan-2-amine HCl; 2-Propanamine, 1,1-difluoro-, hydrochloride; α,α-Difluoroisopropylamine Hydrochloride; (1,1-Difluoropropan-2-yl)amine hydrochloride
EINECS	Contact for details

Quality Control

Our 1,1-Difluoropropan-2-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and Karl Fischer titration, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP and ISO 9001 standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.