Description

(1R,4R)-6'-Bromo-4-Methoxyspiro[Cyclohexane-1,2'-Inden]-1'(3'H)-Imine Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and functional groups. This compound is of significant value for research and development in medicinal chemistry, serving as a critical building block for synthesizing novel therapeutic agents. It is primarily needed by pharmaceutical companies, biotechnology research firms, and academic institutions engaged in drug discovery programs targeting central nervous system (CNS) disorders, oncology, and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of potential drug candidates, particularly those with spirocyclic architectures.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes to develop new molecular entities.
• CNS Drug Development: Serves as a precursor for compounds being investigated for neurological and psychiatric conditions.
• Oncological Research: Employed in the synthesis of molecules designed to modulate specific biological targets in cancer pathways.
• Chemical Biology Probes: Utilized to create tool compounds for studying enzyme function and receptor interactions in biological systems.
• Process Chemistry & Scale-Up: Supports route scouting and optimization from milligram to kilogram scale for pre-clinical and clinical trial material production.

Basic Information

Product Name	(1R,4R)-6'-Bromo-4-Methoxyspiro[Cyclohexane-1,2'-Inden]-1'(3'H)-Imine Hydrochloride
CAS No.	1383985-61-2
Molecular Formula	C16H19BrClNO
Molecular Weight	356.68 g/mol
Synonyms	6'-Bromo-4-methoxyspiro[cyclohexane-1,2'-inden]-1'(3'H)-imine hydrochloride, (1R,4R)-; (1R,4R)-6'-Bromo-4-methoxy-1',2',3',4'-tetrahydrospiro[cyclohexane-1,2'-inden]-1'-imine hydrochloride; Spiro[cyclohexane-1,2'-inden]-1'(3'H)-imine, 6'-bromo-4-methoxy-, hydrochloride, (1R,4R)-; 1383985-61-2; (1R,4R)-6'-Bromo-4-methoxyspiro[cyclohexane-1,2'-inden]-1'-imine HCl.
EINECS	Contact for details

Quality Control

Our (1R,4R)-6'-Bromo-4-Methoxyspiro[Cyclohexane-1,2'-Inden]-1'(3'H)-Imine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing specifications such as chiral purity, assay, and related substances are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.