Description

(R)-2-(5-Fluoro-2-Methylphenyl)Pyrrolidine Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant commercial interest. Its value lies in its defined stereochemistry and functional groups, which are critical for the synthesis of active pharmaceutical ingredients (APIs) and advanced organic molecules. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for drug discovery and process development.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of novel therapeutic agents, particularly in central nervous system (CNS) and psychiatric drug candidates.
• Asymmetric Synthesis: Used as a precursor or catalyst ligand in stereoselective chemical reactions to create enantiomerically pure compounds.
• Agrochemical Research: Serves as a building block for developing new pesticides and herbicides with specific biological activity.
• Academic & Contract Research: Essential material for medicinal chemistry programs and structure-activity relationship (SAR) studies in university and CRO laboratories.
• Process Chemistry: Employed in scale-up and optimization studies for the commercial manufacturing route of target APIs.
• Reference Standard: Used as a high-purity analytical standard for quality control and method validation in regulatory filings.

Basic Information

Product Name	(R)-2-(5-Fluoro-2-Methylphenyl)Pyrrolidine Hydrochloride
CAS No.	1381929-21-0
Molecular Formula	C11H14ClFN
Molecular Weight	213.69 g/mol
Synonyms	(R)-5-Fluoro-2-methyl-α-(pyrrolidin-2-yl)benzyl hydrochloride; (2R)-2-(5-Fluoro-2-methylphenyl)pyrrolidine hydrochloride; (R)-2-(5-Fluoro-o-tolyl)pyrrolidine hydrochloride; (R)-5'-Fluoro-2'-methyl-2-pyrrolidinylbenzhydryl hydrochloride; UNII-7K6J39WJ8F; 7K6J39WJ8F; (R)-2-(5-Fluoro-2-methylphenyl)-pyrrolidine HCl
EINECS	Contact for details

Quality Control

Our (R)-2-(5-Fluoro-2-Methylphenyl)Pyrrolidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) providing batch-specific results for identity, purity, and impurities is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.