Description

(2R)-2-(3-Fluoro-4-Methylphenyl)Pyrrolidine Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant commercial interest. Its value lies in its defined stereochemistry and functionalized aromatic-pyrrolidine scaffold, which is crucial for the research and development of novel bioactive molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for applications in medicinal chemistry and asymmetric synthesis.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of potential drug candidates targeting central nervous system (CNS) disorders, such as dopamine receptor modulators.
• Medicinal Chemistry Research: Used as a scaffold for constructing compound libraries in high-throughput screening (HTS) for new therapeutic agents.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for the development of chiral ligands and organocatalysts.
• Agrochemical Synthesis: Employed in the research phase for creating novel, optically active pesticides and herbicides.
• Chemical Biology Probe Development: Utilized to create molecular probes for studying biological pathways and protein interactions.
• Academic Research: A valuable compound for university and institutional research in organic synthesis and stereochemistry.

Basic Information

Product Name	(2R)-2-(3-Fluoro-4-Methylphenyl)Pyrrolidine Hydrochloride
CAS No.	1381928-38-6
Molecular Formula	C11H14FN•HCl
Molecular Weight	215.69 g/mol (Free base)
Synonyms	(R)-2-(3-Fluoro-4-methylphenyl)pyrrolidine hydrochloride; (2R)-2-(3-Fluoro-4-methylphenyl)pyrrolidine HCl; (R)-3-Fluoro-4-methyl-α-(pyrrolidin-2-yl)benzene hydrochloride; 1381928-38-6; (R)-2-(3-Fluoro-4-methylphenyl)pyrrolidine monohydrochloride; Pyrrolidine, 2-(3-fluoro-4-methylphenyl)-, (2R)-, hydrochloride; (R)-2-(3-Fluoro-p-tolyl)pyrrolidine hydrochloride
EINECS	Contact for details

Quality Control

Our (2R)-2-(3-Fluoro-4-Methylphenyl)Pyrrolidine Hydrochloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) documenting identity, purity (typically >97% by HPLC), enantiomeric excess (typically >98% ee), and related substances is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.