Description

(R)-2-(4-Fluorophenyl)Pyrrolidine Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant commercial importance. This compound is valued for its role in the synthesis of advanced active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders. It is primarily needed by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of novel therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of potential drug candidates, especially for neurological and psychiatric applications.
• Asymmetric Synthesis: Used as a versatile building block in stereoselective chemical synthesis to introduce the (R)-2-(4-fluorophenyl)pyrrolidine moiety.
• Medicinal Chemistry Research: Serves as a critical scaffold for structure-activity relationship (SAR) studies and the discovery of new chemical entities.
• Reference Standard: Employed as an analytical standard for quality control and method development in pharmaceutical analysis.
• Process Chemistry Development: Utilized in scaling up synthetic routes from laboratory to pilot and commercial manufacturing scales.

Basic Information

Item	Details
Product Name	(R)-2-(4-Fluorophenyl)Pyrrolidine Hydrochloride
CAS No.	1381928-30-8
Molecular Formula	C10H12FN•HCl
Molecular Weight	201.67 g/mol
Synonyms	(R)-2-(4-Fluorophenyl)pyrrolidine HCl; (R)-2-(p-Fluorophenyl)pyrrolidine hydrochloride; (R)-4-Fluoro-α-(2-pyrrolidinyl)benzene hydrochloride; (R)-1-(4-Fluorophenyl)-2-pyrrolidinemethane hydrochloride; (R)-NSC 781826 hydrochloride; (R)-FPyrrolidine HCl; (R)-2-(4-Fluorophenyl)-1-azacyclopentane hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-2-(4-Fluorophenyl)Pyrrolidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.