Description

Methyltetrazine-Acid CAS NO 1380500-88-8 is a high-value, functionalized tetrazine derivative used as a critical building block in advanced chemical synthesis. This compound is essential for researchers and manufacturers requiring a reliable, high-purity reagent for click chemistry applications, particularly in bioorthogonal labeling. It is primarily utilized by the pharmaceutical, biotechnology, and materials science industries for the development of novel therapeutics, diagnostic probes, and functional polymers.

Application

• Bioorthogonal Chemistry: A key reagent for inverse electron demand Diels-Alder (IEDDA) click reactions with trans-cyclooctenes (TCOs) for live-cell labeling and imaging.
• Bioconjugation: Used for site-specific labeling of proteins, antibodies, and oligonucleotides with fluorescent dyes or other payloads.
• Pre-targeted Radioimmunotherapy: Enables the development of advanced cancer treatment strategies by attaching radioactive isotopes to targeting antibodies.
• Polymer & Materials Science: Serves as a functional monomer or cross-linker for creating smart, responsive hydrogels and surface-modified materials.
• Chemical Biology Probes: Facilitates the creation of activity-based probes for studying enzyme function and cellular processes.
• Diagnostic Agent Development: Integral to synthesizing contrast agents for molecular imaging techniques like PET and fluorescence-guided surgery.

Basic Information

Product Name	Methyltetrazine-Acid
CAS No.	1380500-88-8
Molecular Formula	C5H6N4O2
Molecular Weight	154.13 g/mol
Synonyms	5-Methyl-1,2,4,5-tetrazine-3-carboxylic acid; 3-Methyl-1,2,4,5-tetrazine-6-carboxylic acid; Methyltetrazine carboxylic acid; MeTz-acid; Methyl-Tetrazine-COOH; 6-Methyl-1,2,4,5-tetrazine-3-carboxylic acid; Methyl tetrazine acid; Methyltetrazine COOH
EINECS	Contact for details

Quality Control

Our Methyltetrazine-Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, typically ≥95% (HPLC). Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation via NMR and HPLC, and impurity profiles. We adhere to cGMP principles where applicable to support our customers in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture uptake. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Orange to red solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.