Description

5-Carboxy-2-Fluorocinnamic Acid CAS NO 1380317-47-4 is a high-purity fluorinated cinnamic acid derivative, serving as a critical advanced pharmaceutical intermediate for the synthesis of novel active ingredients. Its unique structure, featuring both a carboxylic acid and a fluorine substituent, makes it a versatile building block for constructing complex molecules with enhanced metabolic stability and bioavailability. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and material science sectors seeking to incorporate fluorinated aromatic motifs.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of fluorinated drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Building block for developing new-generation herbicides and pesticides with improved efficacy and environmental profile.
• Liquid Crystal & OLED Material Research: Used in the development of fluorinated organic semiconductors and liquid crystal compounds for electronic displays.
• Peptide Mimetics & Bioconjugation: The carboxylic acid group enables its use in creating fluorinated peptide analogs or as a linker in bioconjugation chemistry.
• Organic Synthesis Reagent: Serves as a starting material or coupling partner in various cross-coupling and condensation reactions (e.g., Knoevenagel condensation).
• Fluorine-19 NMR Probe: Can be utilized as a molecular probe in magnetic resonance imaging (MRI) research due to the fluorine atom.

Basic Information

Product Name	5-Carboxy-2-Fluorocinnamic Acid
CAS No.	1380317-47-4
Molecular Formula	C10H7FO4
Molecular Weight	210.16 g/mol
Synonyms	2-Fluoro-5-carboxycinnamic Acid; 3-(2-Fluoro-5-carboxyphenyl)acrylic Acid; (2E)-3-(2-Fluoro-5-carboxyphenyl)prop-2-enoic Acid; 5-Carboxy-2-fluorocinnamate; 2-Fluoro-5-carboxyphenylacrylic Acid; 1380317-47-4; 5-Carboxy-2-fluorocinnamicacid
EINECS	Contact for details

Quality Control

Our 5-Carboxy-2-Fluorocinnamic Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for water content. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents. Due to its acidic nature, handle with appropriate personal protective equipment in a fume hood or well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.