Description

(4-{[3-(Trifluoromethyl)Phenyl]Methyl}Oxan-4-Yl)Methanamine Hydrochloride is a high-purity, advanced pharmaceutical intermediate with a distinct trifluoromethylphenyl-tetrahydropyran structural motif. This compound matters for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and other therapeutic areas. Pharmaceutical R&D laboratories and fine chemical manufacturers need this material for its reliable quality and structural specificity, which enables efficient and scalable drug development processes.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates, especially for CNS-targeted therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its unique trifluoromethyl and tetrahydropyran functionalities.
• API Synthesis: Serves as a crucial building block in the multi-step synthesis of complex target molecules for preclinical and clinical trials.
• Chemical Reference Standard: Employed as an analytical standard for quality control and method validation in pharmaceutical manufacturing.
• Process Chemistry Development: Utilized for scaling up synthetic routes from laboratory to pilot plant and commercial production.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in outsourced drug discovery and development services.

Basic Information

Product Name	(4-{[3-(Trifluoromethyl)Phenyl]Methyl}Oxan-4-Yl)Methanamine Hydrochloride
CAS No.	1380300-85-5
Molecular Formula	C14H19ClF3NO
Molecular Weight	309.76 g/mol
Synonyms	1-[(4-{[3-(Trifluoromethyl)benzyl]oxy}tetrahydro-2H-pyran-4-yl)methanamine] hydrochloride; (4-{[3-(Trifluoromethyl)Phenyl]Methyl}Oxan-4-Yl)Methanamine HCl; 4-({[3-(Trifluoromethyl)phenyl]methyl}oxy)tetrahydro-2H-pyran-4-methanamine hydrochloride; 1-(4-((3-(Trifluoromethyl)benzyl)oxy)tetrahydro-2H-pyran-4-yl)methanamine hydrochloride; 1380300-85-5; UNII-8J3K5K3V4F
EINECS	Contact for details

Quality Control

Our (4-{[3-(Trifluoromethyl)Phenyl]Methyl}Oxan-4-Yl)Methanamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.