Description

1-(Cyclobutylmethyl)-4,4-Difluorocyclohexan-1-Amine Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its unique difluorocyclohexyl and cyclobutylmethyl amine structure. This compound is of significant commercial value for its role in the synthesis of novel bioactive molecules, particularly in medicinal chemistry research and development. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in creating next-generation therapeutics, including potential candidates for central nervous system (CNS) and metabolic disorder targets.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of novel active pharmaceutical ingredients (APIs), especially those targeting G-protein-coupled receptors (GPCRs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new drug candidates with improved potency and pharmacokinetic properties.
• Preclinical Development: Serves as a critical material for producing batches of candidate compounds for pharmacological and toxicological evaluation.
• Chemical Biology Probes: Utilized in the development of selective chemical probes for studying biological pathways and target validation.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific synthetic projects requiring this specialized amine scaffold.

Basic Information

Product Name	1-(Cyclobutylmethyl)-4,4-Difluorocyclohexan-1-Amine Hydrochloride
CAS No.	1380300-69-5
Molecular Formula	C11H20ClF2N
Molecular Weight	239.73 g/mol
Synonyms	4,4-Difluoro-1-(cyclobutylmethyl)cyclohexanamine hydrochloride; 1-(Cyclobutylmethyl)-4,4-difluorocyclohexanamine HCl; 4,4-Difluoro-N-(cyclobutylmethyl)cyclohexanamine hydrochloride; (4,4-Difluorocyclohexyl)(cyclobutylmethyl)amine hydrochloride; 1380300-69-5; Amine, 1-(cyclobutylmethyl)-4,4-difluorocyclohexyl-, hydrochloride
EINECS	Contact for details

Quality Control

Our 1-(Cyclobutylmethyl)-4,4-Difluorocyclohexan-1-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting compliance with agreed specifications. Our quality commitment supports applications in GMP and non-GMP pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.