Description

4,4-Difluoro-1-(Pyridin-2-Ylmethyl)Cyclohexan-1-Amine Dihydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its unique difluorocyclohexyl and pyridinylmethylamine structure. This compound matters for its critical role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry research targeting central nervous system (CNS) and metabolic disorders. Pharmaceutical R&D teams and fine chemical manufacturers need this building block for developing new drug candidates, leveraging its fluorine atoms to modulate pharmacokinetic properties like metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key building block in the research and development of novel drug candidates, particularly for CNS-targeted therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize lead compounds, benefiting from the physicochemical influence of the difluoro moiety.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a precursor in multi-step synthetic routes for potential APIs in clinical development.
• Biochemical Research: Employed as a tool compound in biochemical assays and for probing biological targets in academic and industrial research settings.
• Contract Development and Manufacturing (CDMO): Supplied to CDMOs for scale-up synthesis under cGMP conditions for pre-clinical and clinical trial material production.
• Library Synthesis for High-Throughput Screening: Used to create focused chemical libraries for screening against novel biological targets in drug discovery.

Basic Information

Product Name	4,4-Difluoro-1-(Pyridin-2-Ylmethyl)Cyclohexan-1-Amine Dihydrochloride
CAS No.	1380300-54-8
Molecular Formula	C13H19Cl2F2N2
Molecular Weight	309.21 g/mol
Synonyms	1-(Pyridin-2-ylmethyl)-4,4-difluorocyclohexan-1-amine dihydrochloride; 4,4-Difluoro-1-[(pyridin-2-yl)methyl]cyclohexan-1-amine dihydrochloride; 4,4-Difluoro-1-(2-pyridylmethyl)cyclohexylamine dihydrochloride; 1-(2-Pyridinylmethyl)-4,4-difluorocyclohexanamine dihydrochloride; 4,4-Difluoro-1-(pyridin-2-ylmethyl)cyclohexanamine hydrochloride (1:2); 1380300-54-8; 4,4-Difluoro-1-(2-pyridinylmethyl)-cyclohexanamine dihydrochloride
EINECS	Contact for details

Quality Control

Our 4,4-Difluoro-1-(Pyridin-2-Ylmethyl)Cyclohexan-1-Amine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with the standards expected for pharmaceutical R&D and cGMP intermediate production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.