Description

Methyl 6-(Difluoromethyl)Picolinate is a high-value, fluorinated pyridine derivative serving as a critical synthetic intermediate. Its core value lies in the strategic incorporation of a difluoromethyl group, which is pivotal for modulating the physicochemical and metabolic properties of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients with enhanced efficacy and stability.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethyl group improves biological activity and environmental profile.
• Material Science Research: Serves as a precursor for specialty chemicals and functional materials, including liquid crystals and organic electronic components.
• Chemical Biology & Proteomics: Employed as a tool compound or labeling reagent in biochemical research for studying enzyme mechanisms and protein interactions.
• Custom Synthesis & Contract Manufacturing: A versatile starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	Methyl 6-(Difluoromethyl)Picolinate
CAS No.	1379375-24-2
Molecular Formula	C8H7F2NO2
Molecular Weight	187.14 g/mol
Synonyms	6-(Difluoromethyl)picolinic acid methyl ester; Methyl 6-(difluoromethyl)pyridine-2-carboxylate; 2-Pyridinecarboxylic acid, 6-(difluoromethyl)-, methyl ester; Methyl 2-(difluoromethyl)pyridine-6-carboxylate (regioisomer); 6-Difluoromethyl-picolinic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 6-(Difluoromethyl)Picolinate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider holding under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.