Description

Bicyclo[1.1.1]pentane-1,3-dicarboxamide is a high-value, structurally constrained dicarboxamide derivative featuring the rigid bicyclo[1.1.1]pentane (BCP) scaffold. This compound is of significant interest in modern medicinal chemistry and materials science as a versatile synthetic intermediate and a bioisostere for para-substituted benzene rings or tert-butyl groups, offering improved metabolic stability and physicochemical properties. It is primarily utilized by pharmaceutical R&D teams, agrochemical innovators, and advanced material scientists for the development of novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing drug candidates targeting CNS disorders, oncology, and metabolic diseases, leveraging its 3D structure to enhance binding affinity and reduce lipophilicity.
• Agrochemical Research: Used in the design of novel herbicides, fungicides, and insecticides where the BCP core can improve photostability and bioavailability.
• Material Science Precursor: Serves as a monomer or cross-linking agent for creating high-performance polymers with tailored rigidity, thermal stability, and low dielectric constants for electronic applications.
• Chemical Biology Probe: Incorporated into molecular probes and bioconjugation reagents to study protein-ligand interactions and cellular processes due to its metabolic resistance and small steric profile.
• Ligand & Catalyst Development: Employed in organometallic chemistry to create novel chelating ligands for catalysis, benefiting from the unique spatial geometry of the BCP unit.
• Academic & Discovery Chemistry: Fundamental research reagent for exploring new synthetic methodologies and the properties of strained hydrocarbon bioisosteres.

Basic Information

Item	Details
Product Name	Bicyclo[1.1.1]pentane-1,3-dicarboxamide
CAS No.	1379318-53-2
Molecular Formula	C8H10N2O2
Molecular Weight	166.18 g/mol
Synonyms	1,3-Bicyclo[1.1.1]pentanedicarboxamide; BCP-1,3-dicarboxamide; [1.1.1]Propellane-1,3-dicarboxamide (derived); 3-Carbamoylbicyclo[1.1.1]pentane-1-carboxamide; Bicyclo[1.1.1]pentane-1,3-dicarboxylic acid diamide
EINECS	Contact for details

Quality Control

Our Bicyclo[1.1.1]pentane-1,3-dicarboxamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our production adheres to cGMP principles where applicable, supporting its use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation from moisture uptake. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.