Description

6'-Bromo-1'H-Spiro[Cyclopropane-1,3'-Indole]-2'-One is a high-value, spirocyclic indole derivative featuring a bromine substituent and a fused cyclopropane ring. This unique molecular architecture makes it a critical advanced pharmaceutical intermediate (API) and a versatile building block for medicinal chemistry research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors for the synthesis of novel therapeutic agents, particularly in oncology and CNS drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially those targeting protein-protein interactions.
• Medicinal Chemistry Research: Serves as a privileged scaffold for constructing compound libraries for high-throughput screening (HTS) and structure-activity relationship (SAR) studies.
• Oncology Drug Development: Used in the research and development of small-molecule inhibitors and targeted cancer therapies.
• CNS-Active Compound Synthesis: Employed as a building block for novel molecules intended to cross the blood-brain barrier for neurological applications.
• Chemical Biology Probes: Utilized in the development of chemical probes to study specific biological pathways and enzyme functions.
• Process Chemistry & Scale-Up: Supplied for route scouting, optimization, and pilot-scale production of clinical trial materials.

Basic Information

Product Name	6'-Bromo-1'H-Spiro[Cyclopropane-1,3'-Indole]-2'-One
CAS No.	1378865-57-6
Molecular Formula	C10H8BrNO
Molecular Weight	238.08 g/mol
Synonyms	6'-Bromo-1'H-spiro[cyclopropane-1,3'-indol]-2'(1'H)-one; 6'-Bromospiro[cyclopropane-1,3'-indolin]-2'-one; 1'H-Spiro[cyclopropane-1,3'-indole]-2'-one, 6'-bromo-; Spiro[cyclopropane-1,3'-indole]-2'-one, 6'-bromo-1'H-; 6-Bromospiro[cyclopropane-1,3'-indolin]-2'-one; 6'-Bromo-1'H-spiro[cyclopropane-1,3'-indol]-2'-one; Bromo-spirocyclopropane-indolone; 1378865-57-6
EINECS	Contact for details

Quality Control

Our 6'-Bromo-1'H-Spiro[Cyclopropane-1,3'-Indole]-2'-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency, meeting the stringent requirements of pharmaceutical R&D. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under inert atmosphere when appropriate for prolonged use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.