Description

tert-Butyl n-(2-Aminocyclobutyl)Carbamate is a specialized Boc-protected cyclobutylamine derivative, serving as a critical chiral building block in advanced organic synthesis. Its value lies in providing a protected primary amine functionality on a strained four-membered ring, enabling precise molecular construction while preventing unwanted side reactions. This high-purity intermediate is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for constructing novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), especially in protease inhibitor and kinase inhibitor research.
• Peptidomimetic Chemistry: Used in the synthesis of conformationally constrained peptide analogs, where the cyclobutane ring introduces unique structural and bioactive properties.
• Agrochemical Synthesis: Building block for creating new generations of herbicides and fungicides with enhanced selectivity and efficacy.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced organic materials with tailored properties.
• Chemical Biology Probes: Useful for labeling and modifying biomolecules to study biological pathways and protein interactions.

Basic Information

Product Name	tert-Butyl n-(2-Aminocyclobutyl)Carbamate
CAS No.	1378864-01-7
Molecular Formula	C9H18N2O2
Molecular Weight	186.25 g/mol
Synonyms	Boc-2-Aminocyclobutane; 2-((tert-Butoxycarbonyl)amino)cyclobutanamine; 1-N-Boc-2-aminocyclobutane; tert-Butyl (2-aminocyclobutyl)carbamate; 2-Aminocyclobutylcarbamic acid tert-butyl ester; (2-Aminocyclobutyl)carbamic acid 1,1-dimethylethyl ester; N-Boc-1,2-cyclobutanediamine (ambiguous, verify isomer); 2-N-Boc-aminocyclobutane
EINECS	Contact for details

Quality Control

Our tert-Butyl n-(2-Aminocyclobutyl)Carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for research and process development. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.