Description

2-Aminospiro[3.3]heptane-2-carboxylic acid is a high-value, conformationally constrained non-proteinogenic amino acid featuring a unique spirocyclic scaffold. This structural motif is of significant interest in advanced pharmaceutical research and development, particularly for creating novel peptide-based therapeutics with enhanced metabolic stability and binding selectivity. It serves as a critical building block for medicinal chemists and researchers in the pharmaceutical, biotechnology, and agrochemical sectors seeking to explore new chemical space and develop next-generation bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, especially in peptide mimetics and protease inhibitors.
• Peptidomimetic Design: Used to introduce rigid, three-dimensional structural constraints into peptide backbones to improve bioavailability and receptor selectivity.
• Chemical Biology Probe Development: Employed in the creation of specialized amino acids for studying protein-protein interactions and enzyme mechanisms.
• Agrochemical Research: Serves as a building block for developing new active ingredients with unique modes of action.
• Material Science: Potential monomer for synthesizing specialty polymers with tailored properties.
• Academic & Contract Research: Essential for exploratory synthetic chemistry and methodology development in academic and industrial R&D laboratories.

Basic Information

Product Name	2-Aminospiro[3.3]heptane-2-carboxylic Acid
CAS No.	1378703-61-7
Molecular Formula	C8H13NO2
Molecular Weight	155.19 g/mol
Synonyms	2-Azaspiro[3.3]heptane-2-carboxylic acid, 6-amino-; 6-Amino-2-azaspiro[3.3]heptane-2-carboxylic acid; 2-Amino-2-carboxyspiro[3.3]heptane; Spiro[3.3]heptane-2-carboxylic acid, 2-amino-; 2-Aminospiro[3.3]heptane-2-carboxylic acid; 2-Amino-2-azaspiro[3.3]heptane-6-carboxylic acid (tautomer); Constrained bicyclic amino acid; NSC 870903
EINECS	Contact for details

Quality Control

Our 2-Aminospiro[3.3]heptane-2-carboxylic acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral assay, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.