Description

1-Cyclohexyl-2,2,2-trifluoroethan-1-amine hydrochloride is a high-purity, fluorinated amine hydrochloride salt of significant interest in advanced organic synthesis. This compound matters as a versatile and valuable building block for the development of novel pharmaceutical intermediates and agrochemicals, where the introduction of a trifluoromethyl group can dramatically alter biological activity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for introducing the pharmacologically advantageous trifluoroethylamine moiety.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance lipophilicity and environmental stability.
• Ligand and Catalyst Development: Acts as a precursor for chiral amines and ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of fluorinated polymers and specialty materials with unique surface properties and chemical resistance.
• Chemical Biology Probes: Useful for labeling and modifying biomolecules in proteomics and diagnostic assay development due to its reactive amine handle.

Basic Information

Product Name	1-Cyclohexyl-2,2,2-trifluoroethan-1-amine hydrochloride
CAS No.	1376357-98-0
Molecular Formula	C8H15F3N·HCl
Molecular Weight	221.66 g/mol
Synonyms	1-Cyclohexyl-2,2,2-trifluoroethylamine hydrochloride; α-(Trifluoromethyl)cyclohexanemethylamine hydrochloride; (1-Cyclohexyl-2,2,2-trifluoroethyl)amine hydrochloride; 2,2,2-Trifluoro-1-cyclohexylethanamine hydrochloride; Cyclohexyl(trifluoromethyl)methylamine hydrochloride; N-(2,2,2-Trifluoro-1-cyclohexylethyl)amine hydrochloride; 1-Amino-2,2,2-trifluoro-1-cyclohexylethane hydrochloride
EINECS	Contact for details

Quality Control

Our 1-Cyclohexyl-2,2,2-trifluoroethan-1-amine hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and process chemistry. Comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.