Description

1-(2-Chloro-6-Fluorophenyl)Ethan-1-Amine Hydrochloride is a high-purity, pharmaceutically relevant organic salt, serving as a critical building block in modern synthetic chemistry. Its primary value lies in its role as a versatile chiral amine intermediate, essential for constructing complex molecular architectures with specific biological activity. This compound is particularly vital for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to synthesize novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and anti-infective drug candidates.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorinated phenyl ring confers desirable properties like metabolic stability and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for creating chiral ligands and organocatalysts used in asymmetric synthesis to produce enantiomerically pure compounds.
• Chemical Research & Development: Employed in academic and industrial R&D labs for method development, structure-activity relationship (SAR) studies, and exploring new chemical spaces.
• Fine Chemical Production: Integral to the multi-step synthesis of complex, high-value specialty chemicals used in electronics, materials science, and diagnostics.

Basic Information

Item	Detail
Product Name	1-(2-Chloro-6-Fluorophenyl)Ethan-1-Amine Hydrochloride
CAS No.	1375474-27-3
Molecular Formula	C8H10Cl2FN
Molecular Weight	210.08 g/mol
Synonyms	1-(2-Chloro-6-fluorophenyl)ethanamine hydrochloride; α-Methyl-2-chloro-6-fluoro-benzylamine hydrochloride; (1-(2-Chloro-6-fluorophenyl)ethyl)amine hydrochloride; 2-Chloro-6-fluoro-α-methylbenzylamine hydrochloride; (R/S)-1-(2-Chloro-6-fluorophenyl)ethanamine hydrochloride; 1-Amino-1-(2-chloro-6-fluorophenyl)ethane hydrochloride; 2-Chloro-6-fluoro-α-methylbenzylamine HCl
EINECS	Contact for details

Quality Control

Our production of 1-(2-Chloro-6-Fluorophenyl)Ethan-1-Amine Hydrochloride adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical testing, including HPLC, NMR, and chiral purity analysis, to meet the exacting standards required for pharmaceutical intermediate applications. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment, ensuring full traceability and compliance with cGMP principles where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (or as specified)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.