Description

2-(2-Bromophenyl)-2,2-Difluoroacetic Acid is a high-value, multi-functional fluorinated building block essential for advanced organic synthesis. This compound is critical for introducing the difluoroacetate moiety into complex molecular architectures, enabling the fine-tuning of physical and biological properties. It is primarily sought after by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for incorporating fluorinated motifs to enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and insecticides where the difluoroacetic acid group can improve efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of fluorinated polymers and liquid crystals, where the bromophenyl group offers a site for further functionalization.
• Chemical Biology Probes: Useful for labeling and modifying biomolecules to study biological processes and protein interactions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses serving the fine chemical and life science industries.

Basic Information

Product Name	2-(2-Bromophenyl)-2,2-Difluoroacetic Acid
CAS No.	1375472-90-4
Molecular Formula	C8H5BrF2O2
Molecular Weight	251.03 g/mol
Synonyms	2-Bromo-α,α-difluorophenylacetic Acid; (2-Bromophenyl)difluoroacetic Acid; α,α-Difluoro-2-bromophenylacetic Acid; 2-(2-Bromophenyl)-2,2-difluoroethanoic Acid; Difluoro(2-bromophenyl)acetic Acid; 2-Bromo-α,α-difluorobenzeneacetic Acid; 1375472-90-4; 2-(2-Bromophenyl)-2,2-difluoroacetic acid
EINECS	Contact for details

Quality Control

Our 2-(2-Bromophenyl)-2,2-Difluoroacetic Acid is manufactured under strict quality management systems. Every batch is subjected to rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.