Description

Chloro[(Tri-tert-Butylphosphine)-2-(2-Aminobiphenyl)]Palladium(II) is a highly active and versatile Buchwald-Hartwig palladium catalyst. This compound is specifically engineered to facilitate challenging C–N and C–O bond-forming cross-coupling reactions with superior efficiency and selectivity. It is an essential reagent for process chemists and researchers in pharmaceutical development, agrochemical synthesis, and advanced materials science, where reliable, high-yielding amination protocols are critical.

Application

• Pharmaceutical Intermediate Synthesis: Key catalyst for the large-scale production of active pharmaceutical ingredients (APIs) via Buchwald-Hartwig amination.
• Agrochemical Manufacturing: Enables the synthesis of complex amine-containing herbicides, fungicides, and insecticides.
• Advanced Material Development: Used in creating organic electronic materials, such as those for OLEDs, through precise aryl-amine coupling.
• Process Chemistry & Optimization: Valued for its robustness and high turnover numbers (TON) in streamlining manufacturing routes.
• Academic & R&D Laboratories: A preferred pre-catalyst for methodological development and exploring new reaction spaces in cross-coupling.
• Fine Chemical Production: Facilitates the synthesis of specialty amines, ligands, and other high-value chemical building blocks.

Basic Information

Product Name	Chloro[(Tri-tert-Butylphosphine)-2-(2-Aminobiphenyl)]Palladium(II)
CAS No.	1375325-71-5
Molecular Formula	C26H40ClNPPd
Molecular Weight	530.42 g/mol
Synonyms	Chloro(tri-tert-butylphosphine)(2-aminobiphenyl-2-yl)palladium(II); Pd-P(t-Bu)3 G3 Catalyst; Buchwald Palladium Precatalyst G3; (2-Aminobiphenyl)PdCl(P(t-Bu)3); Palladium(II) chloro(2-aminobiphenyl-2-yl)(tri-tert-butylphosphine); Pd-P(t-Bu)3 Aminobiphenyl Complex; Palladium G3 Catalyst; XPhos Pd G3 (related but distinct)
EINECS	Contact for details

Quality Control

Our production of Chloro[(Tri-tert-Butylphosphine)-2-(2-Aminobiphenyl)]Palladium(II) adheres to stringent quality protocols to ensure batch-to-batch consistency and optimal catalytic performance. Each lot is characterized by advanced analytical techniques, including NMR and HPLC, to verify identity, purity, and activity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to maintain stability. This material is hygroscopic (moisture-sensitive) and easily oxidized; ensure containers are sealed immediately after use.

Specification

Item	Specification
Appearance	Yellow to orange-brown crystalline powder
Identification (IR)	Conforms to structure
Assay (Pd content)	≥ 98.0%
Purity (HPLC)	≥ 97.0%
Solubility	Soluble in common organic solvents (THF, Toluene, DCM)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.