Description

Ruphos Pd G2 is a highly active, second-generation palladium precatalyst widely used in cross-coupling reactions. Its significance lies in its exceptional stability and efficiency, enabling challenging transformations under mild conditions with high turnover numbers. This catalyst is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries, where it facilitates the synthesis of complex organic molecules. Its robust performance makes it a cornerstone for modern synthetic methodologies.

Application

• Pharmaceutical Intermediate Synthesis: Key catalyst for Buchwald-Hartwig amination, Suzuki-Miyaura, and Negishi cross-coupling reactions in API development.
• Agrochemical Manufacturing: Enables the construction of complex heterocyclic and biaryl structures found in modern active ingredients.
• Materials Science Research: Used in the synthesis of conjugated polymers, organic semiconductors, and ligand frameworks.
• Process Chemistry & Scale-up: Preferred for its air stability and reliable performance in kilogram-scale manufacturing.
• Academic & R&D Laboratories: A staple precatalyst for methodological development and exploring new C-C and C-N bond-forming reactions.
• Fine Chemical Production: Facilitates the synthesis of specialty chemicals, flavors, and fragrances requiring high selectivity.

Basic Information

Product Name	Ruphos Pd G2
CAS No.	1375325-68-0
Molecular Formula	C₄₆H₆₆Cl₂N₂O₂P₂Pd
Molecular Weight	928.28 g/mol
Synonyms	Chloro(2-dicyclohexylphosphino-2',6'-diisopropoxy-1,1'-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II); Dichloro(2-dicyclohexylphosphino-2',6'-diisopropoxy-1,1'-biphenyl)(2-(2-aminoethyl)phenyl)palladium(II); RuPhos Palladium Precatalyst Gen. 2; RuPhos Pd G2; Pd-RuPhos Precatalyst; Palladium(II) RuPhos G2; CAS 1375325-68-0
EINECS	Contact for details

Quality Control

Our Ruphos Pd G2 is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high catalytic performance. Each lot is characterized by NMR, HPLC, and elemental analysis to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing assay, residual solvent content, and heavy metal limits is provided with every shipment. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a freezer. The product is hygroscopic (moisture-sensitive) and easily oxidized; containers must be sealed immediately after use to minimize exposure to air and moisture. For long-term stability, store in the original sealed vial.

Specification

Item	Specification
Appearance	Yellow to orange-brown solid
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Palladium (Pd) Content	10.5 - 11.5 %
Residual Solvents (GC)	Meet ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.