Description

Sphos Pd G2 CAS NO 1375325-64-6 is a highly active, second-generation palladium catalyst featuring the bulky, electron-rich SPhos ligand, which provides exceptional stability and reactivity. This catalyst is specifically engineered to facilitate challenging cross-coupling reactions, such as Suzuki-Miyaura and Buchwald-Hartwig aminations, with high efficiency and broad substrate tolerance. It is an indispensable tool for researchers and process chemists in pharmaceutical development, agrochemical synthesis, and advanced materials science, where reliable and scalable catalytic performance is critical.

Application

• Pharmaceutical Intermediate Synthesis: Enables key carbon-carbon and carbon-nitrogen bond-forming steps in the production of active pharmaceutical ingredients (APIs).
• Agrochemical Manufacturing: Used in the synthesis of complex, functionalized molecules for novel herbicides, fungicides, and insecticides.
• Polymer & Material Science: Catalyzes the polymerization and functionalization of monomers for creating specialized polymers and electronic materials.
• Academic & Industrial R&D: A preferred catalyst for method development and exploring new synthetic pathways in organic chemistry laboratories.
• Scale-up Process Chemistry: Offers robust performance and air stability, making it suitable for transitioning reactions from milligram to kilogram scale.
• Ligand-Screening Libraries: Serves as a benchmark catalyst in high-throughput screening for reaction optimization.

Basic Information

Item	Detail
Product Name	Sphos Pd G2
CAS No.	1375325-64-6
Molecular Formula	C₄₄H₅₈O₂P₂Pd
Molecular Weight	787.22 g/mol
Synonyms	Chloro(2-dicyclohexylphosphino-2',6'-dimethoxy-1,1'-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II); Dichloro[2-dicyclohexylphosphino-2',6'-dimethoxy-1,1'-biphenyl][2-(2-aminoethyl)phenyl]palladium(II); SPhos Pd G2 Precatalyst; Palladium(II) SPhos G2 complex; XPhos Pd G2 analogue; Buchwald SPhos Palladium Catalyst; Second-Generation SPhos Pd Catalyst
EINECS	Contact for details

Quality Control

Our Sphos Pd G2 is manufactured under strict quality protocols to ensure batch-to-batch consistency and high catalytic performance. Each lot is characterized by advanced analytical techniques, including NMR and HPLC, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing assay, impurity profile, and residual solvent content is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (argon or nitrogen) to maintain long-term stability and prevent decomposition. The material is moisture-sensitive and should be handled in a dry environment.

Specification

Item	Specification
Appearance	Yellow to orange-brown solid
Identification (NMR)	Conforms to structure
Assay (Pd content)	≥ 13.5%
Purity (HPLC)	≥ 95%
Solubility	Soluble in common organic solvents (DCM, THF, toluene)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.