Description

tert-Butyl 1-(Hydroxymethyl)-5-Azaspiro[2.3]Hexane-5-Carboxylate is a high-value, multifunctional spirocyclic building block designed for advanced pharmaceutical synthesis. This compound is critical for medicinal chemists seeking to introduce structural complexity and three-dimensionality into novel drug candidates, potentially enhancing binding affinity and metabolic stability. It is primarily utilized in the research and development of new therapeutic agents, particularly within central nervous system (CNS) and oncology drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex active pharmaceutical ingredients (APIs) and preclinical candidates.
• Medicinal Chemistry Research: Used in fragment-based drug design and lead optimization to explore novel chemical space and improve drug-like properties.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a versatile linker or component in the construction of heterobifunctional molecules for targeted protein degradation.
• CNS Drug Discovery: Employed in the development of compounds targeting neurological disorders due to its spirocyclic scaffold's potential to enhance blood-brain barrier penetration.
• Chemical Biology Probes: Utilized to create tool compounds for studying enzyme function and biological pathways.
• Asymmetric Synthesis: Acts as a valuable starting material or intermediate in stereoselective synthesis routes.

Basic Information

Product Name	tert-Butyl 1-(Hydroxymethyl)-5-Azaspiro[2.3]Hexane-5-Carboxylate
CAS No.	1375303-98-2
Molecular Formula	C11H19NO3
Molecular Weight	213.27 g/mol
Synonyms	5-Azaspiro[2.3]hexane-5-carboxylic acid, 1-(hydroxymethyl)-, 1,1-dimethylethyl ester; 1,1-Dimethylethyl 1-(hydroxymethyl)-5-azaspiro[2.3]hexane-5-carboxylate; tert-Butyl 1-(hydroxymethyl)-5-azaspiro[2.3]hexane-5-carboxylate; 5-tert-Butoxycarbonyl-5-azaspiro[2.3]hexane-1-methanol; Boc-Protected 5-Azaspiro[2.3]hexane-1-methanol; (1-(Hydroxymethyl)-5-azaspiro[2.3]hexan-5-yl)(tert-butoxy)methanone
EINECS	Contact for details

Quality Control

Our tert-Butyl 1-(Hydroxymethyl)-5-Azaspiro[2.3]Hexane-5-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity suitable for sensitive pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.