Description

(2S,5R)-1-Boc-2,5-Dimethylpiperazine Hydrochloride CAS NO 1374975-96-8 is a high-purity, stereochemically defined chiral piperazine derivative used as a critical building block in advanced organic synthesis. This compound is essential for researchers and manufacturers requiring precise stereochemistry and Boc-protected amine functionality for constructing complex molecules. It is primarily utilized in the pharmaceutical industry for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel drug candidates, especially for neurological and psychiatric applications.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its defined stereochemistry and protected amine group.
• Peptidomimetic Synthesis: Serves as a constrained scaffold for designing and synthesizing peptide mimics with enhanced metabolic stability and bioavailability.
• Ligand and Catalyst Development: Employed in the creation of chiral ligands for asymmetric catalysis and organocatalysts.
• Chemical Biology Probes: Utilized in the development of molecular probes to study biological pathways and protein function.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis organizations (CSOs) and CDMOs producing complex molecules under cGMP.

Basic Information

Product Name	(2S,5R)-1-Boc-2,5-Dimethylpiperazine Hydrochloride
CAS No.	1374975-96-8
Molecular Formula	C11H23ClN2O2
Molecular Weight	250.77 g/mol
Synonyms	1-Boc-(2S,5R)-2,5-Dimethylpiperazine Hydrochloride; tert-Butyl (2S,5R)-2,5-dimethylpiperazine-1-carboxylate hydrochloride; (2S,5R)-2,5-Dimethyl-1-(tert-butoxycarbonyl)piperazine hydrochloride; (2S,5R)-1-(tert-Butoxycarbonyl)-2,5-dimethylpiperazine hydrochloride; Boc-2,5-dimethylpiperazine HCl (stereoisomer); (S,R)-1-Boc-2,5-Dimethylpiperazine HCl; Piperazine, 2,5-dimethyl-, 1-(1,1-dimethylethyl) ester, hydrochloride, (2S,5R)-
EINECS	Contact for details

Quality Control

Our (2S,5R)-1-Boc-2,5-Dimethylpiperazine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to confirm stereochemical purity and identity, ensuring it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing purity, chiral excess, and impurity profiles is provided with every shipment. We support development from research to commercial scale with consistent quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% de
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.