Description

2,4-Dichloro-6-Fluoro-7-Bromoquinazoline is a high-value halogenated quinazoline derivative, a crucial advanced pharmaceutical intermediate (API) in modern drug discovery. Its multi-halogenated structure makes it a versatile and reactive scaffold for constructing complex molecules, particularly in the development of kinase inhibitors and targeted cancer therapies. This compound is essential for research and production in pharmaceutical, agrochemical, and advanced material synthesis, where precise molecular architecture is required.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of tyrosine kinase inhibitors (TKIs) and other small-molecule therapeutic agents.
• Oncology Drug Development: Serves as a core scaffold in the research and production of novel anti-cancer compounds targeting specific cellular pathways.
• Agrochemical Synthesis: Used in the development of advanced herbicides and fungicides, leveraging its bioactive quinazoline core.
• Chemical Research & Development: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Material Science: Potential precursor for the synthesis of organic electronic materials and liquid crystals due to its planar, aromatic structure.

Basic Information

Product Name	2,4-Dichloro-6-Fluoro-7-Bromoquinazoline
CAS No.	1374208-44-2
Molecular Formula	C8H2BrCl2FN2
Molecular Weight	295.92 g/mol
Synonyms	7-Bromo-2,4-dichloro-6-fluoroquinazoline; 2,4-Dichloro-6-fluoro-7-bromoquinazoline; Quinazoline, 7-bromo-2,4-dichloro-6-fluoro-; 1374208-44-2; 7-Bromo-2,4-dichloro-6-fluoro-quinazoline; 6-Fluoro-7-bromo-2,4-dichloroquinazoline
EINECS	Contact for details

Quality Control

Our 2,4-Dichloro-6-Fluoro-7-Bromoquinazoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency suitable for sensitive pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.