Description

9,9-Difluoro-2,7-Diaza-Spiro[4.5]Decan-1-One-7-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic and diaza scaffold. This compound is valued for its role as a critical building block in modern medicinal chemistry, enabling the synthesis of novel bioactive molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for drug discovery programs targeting a range of therapeutic areas.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for small molecule drug candidates.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to introduce conformational constraint and fluorine atoms, which can improve metabolic stability and binding affinity.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential component for constructing linkers or warheads due to its spirocyclic structure and functional groups.
• Chemical Biology Probes: Employed in the development of tool compounds for investigating biological pathways and target validation.
• Process Chemistry & Scale-Up: Supports the development of robust and scalable synthetic routes from milligram to kilogram scale for clinical trial material production.

Basic Information

Product Name	9,9-Difluoro-2,7-Diaza-Spiro[4.5]Decan-1-One-7-Carboxylic Acid tert-Butyl Ester
CAS No.	1373502-80-7
Molecular Formula	C13H20F2N2O3
Molecular Weight	290.31 g/mol
Synonyms	tert-Butyl 9,9-difluoro-1-oxo-2,7-diazaspiro[4.5]decane-7-carboxylate; 2,7-Diaza-spiro[4.5]decan-1-one, 9,9-difluoro-7-[(1,1-dimethylethoxy)carbonyl]-; 7-Boc-9,9-difluoro-2,7-diazaspiro[4.5]decan-1-one; 9,9-Difluoro-1-oxo-2,7-diazaspiro[4.5]decane-7-carboxylic acid tert-butyl ester; 9,9-Difluoro-2,7-diazaspiro[4.5]decan-1-one-7-carboxylic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 9,9-Difluoro-2,7-Diaza-Spiro[4.5]Decan-1-One-7-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and MS, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.