Description

(R)-6-Fluoro-1,2,3,4-Tetrahydro-Naphthalen-1-Ylamine Hydrochloride is a high-purity chiral amine building block, essential for the synthesis of complex pharmaceutical intermediates. Its value lies in providing a stereochemically defined, fluorinated tetralin scaffold, which is a privileged structure in medicinal chemistry for modulating biological activity and pharmacokinetic properties. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries, particularly those focused on central nervous system (CNS) and cardiovascular drug discovery programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore the impact of fluorination and stereochemistry on drug candidate profiles.
• CNS Drug Development: Serves as a core building block for potential therapeutics targeting neurological disorders, leveraging the tetralin moiety's affinity for relevant receptors.
• Agrochemical Synthesis: Employed in the creation of advanced, optically active crop protection agents and pesticides.
• Asymmetric Catalysis Studies: Acts as a substrate or ligand precursor in the development of new chiral catalysts and synthetic methodologies.
• Reference Standard: Used as a high-purity analytical standard for quality control and method validation in regulatory submissions.

Basic Information

Product Name	(R)-6-Fluoro-1,2,3,4-Tetrahydro-Naphthalen-1-Ylamine Hydrochloride
CAS No.	1373232-18-8
Molecular Formula	C₁₀H₁₃ClFN
Molecular Weight	201.67 g/mol
Synonyms	(1R)-6-Fluoro-1,2,3,4-tetrahydronaphthalen-1-amine hydrochloride; (R)-6-Fluoro-1,2,3,4-tetrahydro-1-naphthylamine hydrochloride; (R)-1-Amino-6-fluoro-1,2,3,4-tetrahydronaphthalene hydrochloride; (R)-6-Fluoro-1,2,3,4-tetrahydro-1-naphthalenamine hydrochloride; (R)-6-Fluoro-1,2,3,4-tetrahydro-naphthalen-1-ylamine HCl; 6-Fluoro-(1R)-1,2,3,4-tetrahydro-1-naphthalenamine hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-6-Fluoro-1,2,3,4-Tetrahydro-Naphthalen-1-Ylamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to ensure high enantiomeric purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); containers must be kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.