Description

4-Chloro-5H,6H,7H-Pyrrolo[3,4-D]Pyrimidine Hcl is a high-purity, advanced pharmaceutical intermediate belonging to the fused pyrrolopyrimidine class of heterocyclic compounds. This compound is a critical building block in modern medicinal chemistry, valued for its role in constructing complex molecular architectures with targeted biological activity. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly kinase inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the research and development of new active pharmaceutical ingredients (APIs).
• Kinase Inhibitor Synthesis: A core scaffold for constructing potent and selective kinase inhibitors targeting various disease pathways.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies for drug discovery programs.
• Biochemical Tool Compound: Employed in biochemical assays to study enzyme function and cellular signaling mechanisms.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis and scale-up projects.

Basic Information

Product Name	4-Chloro-5H,6H,7H-Pyrrolo[3,4-D]Pyrimidine Hydrochloride
CAS No.	1373228-90-0
Molecular Formula	C6H7ClN3•HCl
Molecular Weight	192.06 g/mol (Free base: 156.59 g/mol)
Synonyms	4-Chloro-5,6,7,8-tetrahydropyrrolo[3,4-d]pyrimidine hydrochloride; 4-Chloro-5,6,7,8-tetrahydropyrrolo[3,4-d]pyrimidine HCl; 4-Chloro-5,6,7,8-tetrahydro-pyrrolo[3,4-d]pyrimidine hydrochloride; Pyrrolo[3,4-d]pyrimidine, 4-chloro-5,6,7,8-tetrahydro-, hydrochloride (1:1); 4-Chloro-5,6,7,8-tetrahydropyrrolo[3,4-d]pyrimidine monohydrochloride
EINECS	Contact for details

Quality Control

Our 4-Chloro-5H,6H,7H-Pyrrolo[3,4-D]Pyrimidine Hcl is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D and pre-clinical development. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥95% by HPLC), identity confirmation (IR, NMR), and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and handling properties. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.