Description

4-Chloro-5,6,7,8-Tetrahydro-Quinolin-8-Ol is a versatile heterocyclic building block and key synthetic intermediate of significant interest in advanced organic synthesis. Its unique fused ring structure, featuring both a chlorinated quinoline core and a tetrahydro modification with a hydroxyl group, makes it a valuable precursor for constructing complex molecular architectures. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a critical scaffold for the synthesis of potential drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging its halogenated heterocyclic structure.
• Ligand and Catalyst Development: Acts as a precursor for creating novel chelating ligands in coordination chemistry and catalysis due to the nitrogen and oxygen donor atoms.
• Material Science Research: Employed in the synthesis of organic electronic materials, dyes, and photoactive compounds.
• Chemical Biology Probes: Utilized as a building block for developing molecular probes to study biological pathways and enzyme functions.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects requiring this specific molecular framework.

Basic Information

Product Name	4-Chloro-5,6,7,8-Tetrahydro-Quinolin-8-Ol
CAS No.	1373223-49-4
Molecular Formula	C9H10ClNO
Molecular Weight	183.63 g/mol
Synonyms	4-Chloro-5,6,7,8-tetrahydroquinolin-8-ol; 8-Hydroxy-4-chloro-5,6,7,8-tetrahydroquinoline; 4-Chloro-8-hydroxy-5,6,7,8-tetrahydroquinoline; 5,6,7,8-Tetrahydro-4-chloro-8-quinolinol; 4-Chloro-8-hydroxy-1,2,3,4-tetrahydroquinoline (tautomeric form); 4-Chloro-8-quinolinol, 5,6,7,8-tetrahydro-; 1373223-49-4 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our 4-Chloro-5,6,7,8-Tetrahydro-Quinolin-8-Ol is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our commitment to quality supports applications in GMP and ISO-compliant environments, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound may be light-sensitive and should be handled under an inert atmosphere for long-term storage to prevent potential oxidation. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.