Description

2-Boc-1,2,3,4-Tetrahydro-[2,7]Naphthyridine is a high-purity, protected heterocyclic building block of significant value in advanced organic synthesis. Its core value lies in serving as a versatile and critical intermediate for constructing complex molecular architectures, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on novel drug candidates, especially within the fields of central nervous system (CNS) and oncology therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) targeting various disease pathways.
• Medicinal Chemistry Research: Used extensively in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR).
• Protecting Group Strategy: The tert-butoxycarbonyl (Boc) group allows for selective manipulation of the naphthyridine nitrogen during multi-step syntheses.
• Library Synthesis: Enables the rapid generation of diverse compound libraries for high-throughput screening in drug discovery.
• Process Chemistry Development: Employed in scaling up synthetic routes from milligram to kilogram scale for clinical trial material production.
• Ligand and Catalyst Development: Potential use in creating novel ligands for catalysis or as a core structure in functional materials.

Basic Information

Product Name	2-Boc-1,2,3,4-Tetrahydro-[2,7]Naphthyridine
CAS No.	1373223-07-4
Molecular Formula	C13H18N2O2
Molecular Weight	234.30 g/mol
Synonyms	1,2,3,4-Tetrahydro-[2,7]naphthyridine-2-carboxylic acid tert-butyl ester; tert-Butyl 1,2,3,4-tetrahydro-[2,7]naphthyridine-2-carboxylate; 2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydro-[2,7]naphthyridine; 2-Boc-THN; Boc-protected tetrahydro[2,7]naphthyridine; 2-(tert-Butyloxycarbonyl)-1,2,3,4-tetrahydro[2,7]naphthyridine; 2-Boc-1,2,3,4-tetrahydro[2,7]naphthyridine
EINECS	Contact for details

Quality Control

Our 2-Boc-1,2,3,4-Tetrahydro-[2,7]Naphthyridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect from moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.