Description

tert-Butyl 5-Bromospiro[Indoline-3,3-Piperidine]-1-Carboxylate (Wx106142) is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic indoline-piperidine scaffold. This compound is of critical importance for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel drug candidates. It is primarily needed by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing therapeutics targeting central nervous system (CNS) disorders, oncology, and other complex disease areas.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs) and drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its complex, three-dimensional spirocyclic structure.
• CNS Drug Discovery: Serves as a core scaffold for developing potential therapeutics for neurological and psychiatric conditions.
• Oncology Research: Utilized in the design and synthesis of potential small-molecule inhibitors and targeted cancer therapies.
• Chemical Biology Probes: Acts as a starting material for creating specialized molecular probes to study biological pathways.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific synthetic routes.

Basic Information

Product Name	tert-Butyl 5-Bromospiro[Indoline-3,3-Piperidine]-1-Carboxylate (Wx106142)
CAS No.	1373028-92-2
Molecular Formula	C17H23BrN2O2
Molecular Weight	367.28 g/mol
Synonyms	1-Boc-5-Bromospiro[indoline-3,3'-piperidine]; 5-Bromo-1-(tert-butoxycarbonyl)spiro[indoline-3,3'-piperidine]; tert-Butyl 5-bromo-1,3-dihydrospiro[indene-2,3'-piperidine]-1-carboxylate (related); WX-106142; Wx106142; 5-Bromospiro[indoline-3,3'-piperidine]-1-carboxylic acid tert-butyl ester; Spiro[indoline-3,3'-piperidine]-1-carboxylic acid, 5-bromo-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-Bromospiro[Indoline-3,3-Piperidine]-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, containers should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.