Description

tert-Butyl 2-(Hydroxymethyl)-1-oxa-8-azaspiro[4.5]decane-8-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and oxazolidinone-like structure. This compound is of significant value for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries seeking to develop new therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates, especially those targeting neurological pathways.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing spirocyclic and heterocyclic libraries in drug discovery programs.
• Process Chemistry Development: Serves as a standardized starting material for optimizing scalable and robust API manufacturing routes.
• CNS Drug Development: Its structural motifs are relevant for creating compounds that interact with specific receptors in the brain.
• Antiviral Agent Synthesis: Potential building block for novel protease inhibitors or other antiviral mechanisms.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific projects.
• Academic Research: Used in university and institutional labs for studying synthetic methodology and chemical biology.

Basic Information

Product Name	tert-Butyl 2-(Hydroxymethyl)-1-oxa-8-azaspiro[4.5]decane-8-carboxylate
CAS No.	1373028-78-4
Molecular Formula	C14H25NO4
Molecular Weight	271.35 g/mol
Synonyms	8-Boc-2-(hydroxymethyl)-1-oxa-8-azaspiro[4.5]decane; 1-Oxa-8-azaspiro[4.5]decane-8-carboxylic acid, 2-(hydroxymethyl)-, 1,1-dimethylethyl ester; tert-Butyl 2-(hydroxymethyl)-1-oxa-8-azaspiro[4.5]decane-8-carboxylate; 2-(Hydroxymethyl)-1-oxa-8-azaspiro[4.5]decane-8-carboxylic acid tert-butyl ester; Boc-protected spirocyclic amino alcohol
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-(Hydroxymethyl)-1-oxa-8-azaspiro[4.5]decane-8-carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic data are provided and available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.