Description

2,5-Diazaspiro[3.4]Octan-6-One is a high-value, spirocyclic heterocyclic compound featuring a unique bridged structure. This molecular framework is of significant interest in modern pharmaceutical research and development, particularly as a versatile and constrained scaffold for drug discovery. It serves as a critical building block for medicinal chemists targeting a range of therapeutic areas, including central nervous system (CNS) disorders, oncology, and infectious diseases.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of novel active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Scaffold: Used to create structurally diverse compound libraries for high-throughput screening and structure-activity relationship (SAR) studies.
• Protease Inhibitor Development: The spirocyclic motif is valuable in designing inhibitors for various protease enzymes.
• Kinase Inhibitor Research: Employed in the synthesis of potential kinase inhibitors for cancer and inflammatory disease targets.
• Fragment-Based Drug Discovery (FBDD): Serves as a three-dimensional, "privileged" fragment for constructing novel drug-like molecules.
• Chemical Biology Probes: Utilized in the synthesis of tool compounds for investigating biological pathways and target validation.

Basic Information

Product Name	2,5-Diazaspiro[3.4]Octan-6-One
CAS No.	1373028-77-3
Molecular Formula	C6H10N2O
Molecular Weight	126.16 g/mol
Synonyms	2,5-Diazaspiro[3.4]octan-6-one; 6-Oxo-2,5-diazaspiro[3.4]octane; 2,5-Diazaspiro[3.4]octan-6-one; Spiro[cyclopropane-1,3'-pyrrolidin]-2'-one; 1,4-Diazaspiro[2.3]hexan-5-one (tautomeric form); 1373028-77-3; 2,5-Diaza-spiro[3.4]octan-6-one
EINECS	Contact for details

Quality Control

Our 2,5-Diazaspiro[3.4]Octan-6-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure traceability and compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.