Description

(1R)-2,2',3,3'-Tetrahydro-6,6'-Bis[2,4,6-Tris(1-Methylethyl)Phenyl]-1,1'-Spirobi[1H-Indene]-7,7'-Diol is a high-purity, chiral spirobiindane derivative that serves as a sophisticated ligand precursor or catalyst component in advanced chemical synthesis. Its value lies in its rigid, well-defined stereochemistry and sterically hindered structure, which are critical for inducing high enantioselectivity in asymmetric transformations. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop novel synthetic routes for optically active molecules.

Application

• Asymmetric Catalysis: As a key ligand or precursor for chiral catalysts used in hydrogenation, C-C bond formation, and other enantioselective reactions.
• Pharmaceutical Intermediate Synthesis: For the research and development of active pharmaceutical ingredients (APIs) requiring high optical purity.
• Agrochemical Research: In the synthesis of chiral herbicides, fungicides, and plant growth regulators.
• Material Science: As a building block for chiral polymers or advanced organic frameworks with specific optical properties.
• Academic & Industrial R&D: A valuable tool compound for methodological development in organic and organometallic chemistry.

Basic Information

Product Name	(1R)-2,2',3,3'-Tetrahydro-6,6'-Bis[2,4,6-Tris(1-Methylethyl)Phenyl]-1,1'-Spirobi[1H-Indene]-7,7'-Diol
CAS No.	1372719-98-6
Molecular Formula	C52H66O2
Molecular Weight	723.09 g/mol
Synonyms	(1R)-6,6'-Bis(2,4,6-Triisopropylphenyl)-2,2',3,3'-tetrahydro-1,1'-spirobi[1H-indene]-7,7'-diol; (R)-Spiro[1H-indene-7,7'-indene]-1,1'-diol Derivative; (1R)-H8-BINOL Derivative; Chiral Spirobiindanediol Ligand; (R)-TIP-Spiro Diol; CAS 1372719-98-6; (1R)-TIP-Spiro Diol
EINECS	Contact for details

Quality Control

Our production of this advanced chiral intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high enantiomeric excess. Quality is verified through comprehensive analytical methods including HPLC, chiral HPLC, 1H/13C NMR, and specific rotation measurement. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, chiral purity, and key physicochemical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Specific Rotation	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.