Description

(R)-n-Methyl-n-Phenyl tert-Butane-Sulfinamide CAS NO 1372133-78-2 is a high-purity chiral sulfinamide compound, widely recognized as a versatile and highly effective chiral auxiliary in asymmetric synthesis. Its primary value lies in enabling the stereoselective construction of complex molecules, particularly in the synthesis of chiral amines, which are crucial building blocks in modern pharmaceuticals. This product is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality intermediates for the development of enantiomerically pure active ingredients.

Application

• Chiral Auxiliary in Asymmetric Synthesis: Employed as a key reagent for the stereocontrolled synthesis of chiral amines and amino acid derivatives.
• Pharmaceutical Intermediate: Critical in the research and development of enantiomerically pure Active Pharmaceutical Ingredients (APIs), especially for neurological and cardiovascular drugs.
• Agrochemical Synthesis: Used in the production of chiral herbicides, fungicides, and insecticides where specific stereochemistry is required for optimal activity.
• Catalyst and Ligand Precursor: Serves as a building block for the synthesis of novel chiral ligands used in transition metal catalysis.
• Academic and Industrial R&D: A fundamental tool in organic chemistry laboratories for methodological development and the synthesis of complex natural products.
• Fine Chemical Production: Utilized in the manufacture of specialty chemicals, flavors, and fragrances requiring high enantiomeric purity.

Basic Information

Item	Details
Product Name	(R)-n-Methyl-n-Phenyl tert-Butane-Sulfinamide
CAS No.	1372133-78-2
Molecular Formula	C11H17NOS
Molecular Weight	195.32 g/mol
Synonyms	(R)-N-Methyl-N-phenyl tert-butanesulfinamide; (R)-tert-Butanesulfinamide, N-methyl-N-phenyl-; (R)-2-Methyl-2-propanesulfinamide, N-methyl-N-phenyl-; (R)-N-Methyl-N-phenyl-2-methylpropane-2-sulfinamide; (R)-N-Methyl-N-phenyl-p-toluenesulfinamide (common misnomer); (R)-Ellman's Sulfinamide (N-Methyl variant); (R)-Methyl(phenyl)((R)-tert-butylsulfinyl)amine; (R)-N-Phenyl-N-methyl tert-butanesulfinamide
EINECS	Contact for details

Quality Control

Our (R)-n-Methyl-n-Phenyl tert-Butane-Sulfinamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) and standard purity assays, to ensure it meets the high standards required for sensitive asymmetric synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles is provided with each shipment to guarantee batch-to-batch consistency and support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can compromise product integrity. Keep away from heat sources and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.