Description

8-Bromo-5-Fluoro-6-Methoxyquinoline is a high-purity, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its unique halogenated and methoxylated quinoline structure makes it a versatile intermediate for constructing complex molecular architectures. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors, antimicrobial agents, and other therapeutic small molecules.
• Agrochemical Research: Serves as a building block for developing new herbicides, fungicides, and pesticides, leveraging the bioactivity of the quinoline core.
• Material Science: Used in the research and development of organic electronic materials, such as OLED (Organic Light-Emitting Diode) components and conductive polymers.
• Chemical Synthesis: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic substitution reactions to introduce complex functionalities.
• Ligand and Catalyst Development: Acts as a starting material for synthesizing novel chelating ligands and organocatalysts used in asymmetric synthesis.
• Fluorescent Probe Synthesis: The quinoline scaffold is ideal for creating fluorescent dyes and molecular probes for biochemical sensing and imaging.

Basic Information

Product Name	8-Bromo-5-Fluoro-6-Methoxyquinoline
CAS No.	1369499-08-0
Molecular Formula	C₁₀H₇BrFNO
Molecular Weight	256.07 g/mol
Synonyms	8-Bromo-5-fluoro-6-methoxyquinoline; 5-Fluoro-8-bromo-6-methoxyquinoline; 6-Methoxy-8-bromo-5-fluoroquinoline; Quinoline, 8-bromo-5-fluoro-6-methoxy-; 1369499-08-0; 8-Br-5-F-6-MeO-quinoline
EINECS	Contact for details

Quality Control

Our 8-Bromo-5-Fluoro-6-Methoxyquinoline is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical quality attributes. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided. Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.