Description

6-Nitro-3,4-Dihydro-2H-Quinoline-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its nitro-substituted quinoline core and tert-butyl ester protecting group. This compound matters for its critical role in the synthesis of complex bioactive molecules, offering a versatile scaffold for medicinal chemistry research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to build novel nitrogen-containing heterocycles.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders, infectious diseases, or oncology.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization programs due to its modifiable functional groups.
• Agrochemical Synthesis: Intermediate in the development of novel herbicides, fungicides, or insecticides that utilize the quinoline pharmacophore.
• Fine Chemical Production: Serves as a precursor for the manufacture of specialty chemicals, dyes, and complex organic compounds.
• Academic & Institutional R&D: Utilized in university and government laboratories for fundamental research in organic synthesis and heterocyclic chemistry.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting outsourced drug discovery and development projects.

Basic Information

Item	Detail
Product Name	6-Nitro-3,4-Dihydro-2H-Quinoline-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1368715-58-5
Molecular Formula	C14H16N2O4
Molecular Weight	276.29 g/mol
Synonyms	tert-Butyl 6-nitro-3,4-dihydro-2H-quinoline-1-carboxylate; 6-Nitro-1,2,3,4-tetrahydroquinoline-1-carboxylic acid tert-butyl ester; 1-Boc-6-nitro-1,2,3,4-tetrahydroquinoline; 1-(tert-Butoxycarbonyl)-6-nitro-1,2,3,4-tetrahydroquinoline; 6-Nitro-2H-1,2,3,4-tetrahydroquinoline-1-carboxylic acid tert-butyl ester; 6-Nitro-1-Boc-1,2,3,4-tetrahydroquinoline; 6-Nitro-1,2,3,4-tetrahydroquinoline-1-tert-butyl carboxylate
EINECS	Contact for details

Quality Control

Our 6-Nitro-3,4-Dihydro-2H-Quinoline-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, impurity profile, and physical characteristics. Our quality commitment supports compliance with cGMP guidelines for advanced pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Single Unknown Impurity	≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.