Description

1-Bromo-2-Ethoxy-5-Fluoro-3-Nitrobenzene is a high-purity, multi-functional halogenated aromatic building block. This compound matters for its role as a critical intermediate in the synthesis of complex organic molecules, particularly in advanced pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially those containing fluoro- and nitro-substituted aromatic systems.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the bromo and fluoro substituents modulate biological activity.
• Material Science Research: Serves as a precursor for the development of advanced organic electronic materials, liquid crystals, and functional polymers.
• Cross-Coupling Reactions: The bromine atom makes it a suitable substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to form complex biaryl structures.
• Nucleophilic Aromatic Substitution: The nitro and fluoro groups activate the ring for substitution reactions, enabling further functionalization.
• Dye and Pigment Intermediate: Potential use in the synthesis of specialized nitro-aromatic dyes and pigments.

Basic Information

Product Name	1-Bromo-2-Ethoxy-5-Fluoro-3-Nitrobenzene
CAS No.	1365272-21-4
Molecular Formula	C8H7BrFNO3
Molecular Weight	264.05 g/mol
Synonyms	2-Bromo-1-ethoxy-4-fluoro-5-nitrobenzene; 5-Fluoro-2-bromo-1-ethoxy-3-nitrobenzene; Benzene, 1-bromo-2-ethoxy-5-fluoro-3-nitro-; 1-Bromo-2-ethoxy-5-fluoro-3-nitrobenzene; 1365272-21-4; 2-Ethoxy-5-fluoro-3-nitro-1-bromobenzene
EINECS	Contact for details

Quality Control

Our 1-Bromo-2-Ethoxy-5-Fluoro-3-Nitrobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is available for every shipment upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and away from direct light sources to maintain stability and purity.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.