Description

5-(n-Boc-Amino)-8-Bromoquinoline is a high-purity, protected amine derivative of bromoquinoline, serving as a critical building block in advanced organic synthesis. This compound is valued for its dual functionality, offering both a bromine atom suitable for cross-coupling reactions and a Boc-protected amino group for controlled deprotection and further functionalization. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of complex molecules, including active pharmaceutical ingredients (APIs) and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex heterocyclic scaffolds found in drug discovery and development programs.
• Cross-Coupling Reactions: The bromine substituent enables participation in Suzuki, Buchwald-Hartwig, and other palladium-catalyzed coupling reactions to form new carbon-carbon and carbon-heteroatom bonds.
• Protected Amine Precursor: The tert-butoxycarbonyl (Boc) group provides a stable, orthogonal protecting strategy for the amine functionality during multi-step syntheses.
• Ligand and Catalyst Development: Used in the research and synthesis of novel quinoline-based ligands for catalysis and metal-organic frameworks (MOFs).
• Agrochemical Research: Serves as a building block for developing new crop protection agents and herbicides with quinoline cores.
• Material Science: A precursor for organic electronic materials and fluorescent dyes due to the quinoline structure's photophysical properties.

Basic Information

Product Name	5-(n-Boc-Amino)-8-Bromoquinoline
CAS No.	1365272-14-5
Molecular Formula	C₁₄H₁₅BrN₂O₂
Molecular Weight	323.19 g/mol
Synonyms	8-Bromo-5-[(tert-butoxycarbonyl)amino]quinoline; 5-[(tert-Butoxycarbonyl)amino]-8-bromoquinoline; 5-(Boc-Amino)-8-bromoquinoline; 5-Amino-8-bromoquinoline, N-Boc protected; tert-Butyl (8-bromoquinolin-5-yl)carbamate; Boc-5-Amino-8-bromoquinoline; 1365272-14-5; 8-Bromo-5-(Boc-amino)quinoline
EINECS	Contact for details

Quality Control

Our 5-(n-Boc-Amino)-8-Bromoquinoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP (current Good Manufacturing Practice) requirements for early-phase development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive (store away from light). For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.