Description

(R)-3-(4-Fluorophenyl)Morpholine Hcl is a high-purity chiral building block and pharmaceutical intermediate of significant commercial and research interest. Its value lies in its defined stereochemistry and functionalized morpholine core, which are critical for the development of active pharmaceutical ingredients (APIs) and other fine chemicals. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for synthesizing novel compounds and optimizing synthetic routes.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and other therapeutic areas.
• Asymmetric Synthesis: Used as a chiral ligand or auxiliary in catalytic reactions to induce stereoselectivity.
• Agrochemical Research: Serves as a building block for developing novel pesticides and herbicides with enhanced activity.
• Chemical Biology & Proteomics: Employed in the design and synthesis of molecular probes and tool compounds for biological target validation.
• Process Chemistry: Utilized in scaling up and optimizing manufacturing routes for complex molecules in pilot plants and commercial production.
• Academic Research: A valuable reagent for universities and research institutes studying synthetic methodology, medicinal chemistry, and material science.

Basic Information

Product Name	(R)-3-(4-Fluorophenyl)Morpholine Hydrochloride
CAS No.	1363408-43-8
Molecular Formula	C10H13ClFNO
Molecular Weight	217.67 g/mol
Synonyms	(R)-3-(4-Fluorophenyl)morpholine hydrochloride; (R)-4-(4-Fluorophenyl)morpholin-3-one hydrochloride (tautomer); (R)-3-(p-Fluorophenyl)morpholine HCl; (R)-3-(4-Fluorophenyl)-1,4-oxazinane hydrochloride; (R)-3-(4-Fluorophenyl)morpholine monohydrochloride; (R)-3-(4-Fluorophenyl)-3,4-dihydro-2H-1,4-oxazine hydrochloride; (R)-3-(4-Fluorophenyl)morpholine HCl salt; (R)-3-(4-Fluorophenyl)morpholine, hydrochloride
EINECS	Contact for details

Quality Control

Our production of (R)-3-(4-Fluorophenyl)Morpholine Hcl adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and chiral analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.