Description

Methyl 9-Azabicyclo[3.3.1]Nonane-3-Carboxylate Hydrochloride is a high-purity, advanced pharmaceutical intermediate with the CAS registry number 1363382-45-9. This compound is a critical building block in modern organic synthesis, valued for its rigid bicyclic scaffold which is instrumental in constructing complex molecules with specific three-dimensional geometries. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly within the fields of neurology and medicinal chemistry.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of complex drug candidates, especially those targeting neurological receptors.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Organic Synthesis Building Block: Employed in the construction of complex natural product analogs and other nitrogen-containing heterocycles due to its unique 9-azabicyclo[3.3.1]nonane skeleton.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying biological pathways and enzyme functions.
• Process Chemistry Development: Acts as a starting material for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions for clinical trial material production.

Basic Information

Product Name	Methyl 9-Azabicyclo[3.3.1]Nonane-3-Carboxylate Hydrochloride
CAS No.	1363382-45-9
Molecular Formula	C10H17NO2 • HCl
Molecular Weight	219.71 g/mol (Free base: 183.25 g/mol)
Synonyms	9-Azabicyclo[3.3.1]nonane-3-carboxylic acid methyl ester hydrochloride; Methyl 3-azabicyclo[3.3.1]nonane-9-carboxylate hydrochloride (isomer); 3-Carbonmethoxy-9-azabicyclo[3.3.1]nonane hydrochloride; Tropane derivative intermediate; 9-Azanoradamantane-3-methyl carboxylate HCl; 3-Methoxycarbonyl-9-azabicyclo[3.3.1]nonane hydrochloride
EINECS	Contact for details

Quality Control

Our Methyl 9-Azabicyclo[3.3.1]Nonane-3-Carboxylate Hydrochloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting all critical quality attributes. Our production can be aligned with cGMP guidelines for advanced pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.