Description

1-(Boc-Amino)-3,3-Difluorocyclobutane-1-Methylamine is a high-purity, protected amine building block featuring a rigid, difluorinated cyclobutane scaffold. This compound is critically important for medicinal chemistry research and development, enabling the synthesis of novel bioactive molecules with enhanced metabolic stability and membrane permeability. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers for constructing complex molecular architectures, particularly in the development of protease inhibitors, kinase inhibitors, and other small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, especially in programs targeting metabolic diseases and oncology.
• Protease Inhibitor Development: Used to incorporate the constrained, fluorinated cyclobutane motif into peptide mimetics and inhibitors.
• Kinase Inhibitor Scaffold: Serves as a core building block for creating selective kinase inhibitors due to its ability to modulate binding affinity and selectivity.
• PET Tracer Precursor: Potential use in the synthesis of precursors for Positron Emission Tomography (PET) imaging agents, leveraging the fluorine atoms.
• Agrochemical Research: Employed in the discovery of new active ingredients with improved physicochemical properties.
• Material Science: Exploration into novel monomers for specialty polymers with unique thermal and chemical resistance profiles.

Basic Information

Product Name	1-(Boc-Amino)-3,3-Difluorocyclobutane-1-Methylamine
CAS No.	1363382-43-7
Molecular Formula	C11H20F2N2O2
Molecular Weight	250.29 g/mol
Synonyms	1-(tert-Butoxycarbonylamino)-3,3-difluorocyclobutane-1-methanamine; 1-((tert-Butoxycarbonyl)amino)-3,3-difluorocyclobutane-1-methylamine; N-Boc-1-amino-3,3-difluorocyclobutanemethylamine; 1-Amino-3,3-difluorocyclobutane-1-methanamine, N-Boc-protected; tert-Butyl (1-amino-3,3-difluorocyclobutyl)methylcarbamate; Boc-ADFCM; 1363382-43-7
EINECS	Contact for details

Quality Control

Our 1-(Boc-Amino)-3,3-Difluorocyclobutane-1-Methylamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our production adheres to cGMP guidelines where applicable, ensuring consistency and reliability for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.