Description

5-Boc-5-Azaspiro[2.5]Octane-1-Carboxylic Acid is a high-value, protected spirocyclic amino acid derivative that serves as a critical building block in advanced organic synthesis. Its unique constrained spirocyclic structure is essential for introducing three-dimensional complexity and modulating the physicochemical properties of target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly in medicinal chemistry for drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders and other therapeutic areas requiring rigid, three-dimensional scaffolds.
• Medicinal Chemistry Research: Used extensively in lead optimization and structure-activity relationship (SAR) studies to explore novel chemical space and improve drug-like properties.
• Peptidomimetics & Constrained Peptide Synthesis: Incorporates conformational restraint into peptide backbones, enhancing metabolic stability and biological activity.
• Agrochemical Development: Serves as a building block for novel pesticides and herbicides, where its spirocyclic structure can contribute to unique modes of action.
• Chemical Biology Probe Development: Utilized in the creation of molecular probes to study enzyme function and protein-protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and small-scale API development.

Basic Information

Product Name	5-Boc-5-Azaspiro[2.5]Octane-1-Carboxylic Acid
CAS No.	1363382-36-8
Molecular Formula	C13H21NO4
Molecular Weight	255.31 g/mol
Synonyms	1-[(tert-Butoxy)carbonyl]-5-azaspiro[2.5]octane-5-carboxylic acid; 5-[(tert-Butoxycarbonyl)]-5-azaspiro[2.5]octane-1-carboxylic acid; 5-Azaspiro[2.5]octane-1-carboxylic acid, 5-(1,1-dimethylethyl) ester; 5-Boc-5-azaspiro[2.5]octane-1-carboxylic acid; tert-Butyl 1-carboxy-5-azaspiro[2.5]octane-5-carboxylate; Boc-protected azaspirooctane carboxylic acid; Spirocyclic Boc-amino acid
EINECS	Contact for details

Quality Control

Our 5-Boc-5-Azaspiro[2.5]Octane-1-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and pre-clinical development phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.